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Overcoming diversity with a multi-envelope HIV vaccine

journal contribution
posted on 2004-01-01, 00:00 authored by A Zirkel, B Brown, B Jones, B Sealy, C Coleclough, John StambasJohn Stambas, J Hurwitz, K Slobod, M Bonsignor, P Doherty, P Freiden, S Surman, S Brown, T Lockey, X Zhan
A central obstacle to the design of a global HIV vaccine is viral diversity. Antigenic differences in envelope proteins result in distinct HIV serotypes, operationally defined such that antibodies raised against envelope from one serotype will not bind envelope molecules from a different serotype. The existence of serotypes has presented a similar challenge to vaccine development against other pathogens. In such cases, antigenic diversity has been addressed by vaccine design: for example, the poliovirus vaccine includes 3 serotypes of poliovirus, and Pneumovax® presents a cocktail of 23 pneumococcal variants to the immune system. It is likely that a successful vaccine for HIV must also comprise a cocktail of antigens. Here, data relevant to the development of cocktail vaccines, designed to harness diverse, envelope-specific B-cell and T-cell responses, are reviewed.

History

Journal

Current topics in virology

Volume

4

Publisher

Research Trends

Location

[India]

ISSN

0972-4591

Language

eng

Publication classification

C3.1 Non-refereed articles in a professional journal

Copyright notice

2005, Research Trends

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