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Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation
journal contributionposted on 2002-03-15, 00:00 authored by John StambasJohn Stambas, G Pietersz, I McKenzie, V Nagabhushanam, C Cheers
Clearance of infectious organisms does not always require polarised Th1 or Th2 responses and it may be advantageous for both Th1 and Th2 responses to be elicited for effective protection against an invading pathogen. It was the aim of this study to investigate oxidised mannan as a possible Th1/Th2 adjuvant. Oxidised mannan was conjugated to two candidate antigens and delivered intranasally to mice. Immunisation with the oxidised conjugate resulted in significant antigen specific proliferative responses, IL-2, IFN-γ and IL-4 production when compared to unconjugated controls.
Pagination1877 - 1886
Publication classificationC1.1 Refereed article in a scholarly journal
Copyright noticeCopyright 2002 Elsevier Science Ltd. All rights reserved.
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AdjuvantTh1Th2Oxidised mannanScience & TechnologyLife Sciences & BiomedicineImmunologyMedicine, Research & ExperimentalResearch & Experimental MedicineDELAYED-TYPE HYPERSENSITIVITYMEDIATED IMMUNE-RESPONSEST-CELL CLONEFUSION PROTEINBORDETELLA-PERTUSSISCOMPARATIVE SELECTIVITYCORYNEBACTERIUM-PARVUMPROTECTIVE IMMUNITYCOMPLETE ADJUVANTSMURAMYL DIPEPTIDE