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Oxygen (O2) kinetics during early recovery from peak exercise in patients with type 2 diabetes
journal contribution
posted on 2011-05-01, 00:00 authored by I Levinger, M Varley, G Jerums, D Hare, Steve SeligSteve SeligAims To examine the oxygen (O2) kinetics during early recovery from peak exercise in patients with Type 2 diabetes and to examine whether oxygen O2 recovery is associated with fasting glucose and HbA1c in this population.
Methods Eighty-nine participants (52 men) aged 51.8 ± 7.1 years (mean ± sd) were divided into three groups: normal weight (BMI ≤ 25.0 kg/m2), overweight/obese without diabetes (BMI ≥ 26 kg/m2) and overweight/obese with Type 2 diabetes. Participants were assessed for their aerobic power (VO2peak) on a cycle ergometer, provided a fasting blood sample and underwent a series of anthropometric measurements. Early recovery period was measured for 60 s from cessation of exercise and expressed as percentage of VO2peak (higher percentage represents slower recovery).
Results No significant differences were observed for age between the three study groups. Both the overweight/obese groups without diabetes and with Type 2 diabetes had higher BMI than the normal weight group, with no significant differences between overweight/obese participants without diabetes and those with diabetes. Participants with Type 2 diabetes had lower VO2peak than overweight/obese participants without diabetes and normal weight individuals (19.6 ± 4.8, 22.6 ± 5.4 and 25.7 ± 5.3 ml kg−1 min−1, respectively, P < 0.004 for overall trends). Participants with Type 2 diabetes also had slower recovery in oxygen O2 kinetics after exercise, compared with both normal weight and overweight/obese individuals without diabetes (56.5 ± 7.7, 49.2 ± 7.2, 47.7 ± 7.4%, P < 0.004 for overall trends). Multiple regression analysis revealed that percentage of oxygen O2 recovery was a stronger predictor than VO2peak, BMI or age for fasting glucose and HbA1c.
Conclusions Patients with Type 2 diabetes have lower VO2peak and prolonged oxygen O2 recovery from peak exercise. However, only prolonged oxygen O2 recovery was associated with fasting glucose and HbA1c.
Methods Eighty-nine participants (52 men) aged 51.8 ± 7.1 years (mean ± sd) were divided into three groups: normal weight (BMI ≤ 25.0 kg/m2), overweight/obese without diabetes (BMI ≥ 26 kg/m2) and overweight/obese with Type 2 diabetes. Participants were assessed for their aerobic power (VO2peak) on a cycle ergometer, provided a fasting blood sample and underwent a series of anthropometric measurements. Early recovery period was measured for 60 s from cessation of exercise and expressed as percentage of VO2peak (higher percentage represents slower recovery).
Results No significant differences were observed for age between the three study groups. Both the overweight/obese groups without diabetes and with Type 2 diabetes had higher BMI than the normal weight group, with no significant differences between overweight/obese participants without diabetes and those with diabetes. Participants with Type 2 diabetes had lower VO2peak than overweight/obese participants without diabetes and normal weight individuals (19.6 ± 4.8, 22.6 ± 5.4 and 25.7 ± 5.3 ml kg−1 min−1, respectively, P < 0.004 for overall trends). Participants with Type 2 diabetes also had slower recovery in oxygen O2 kinetics after exercise, compared with both normal weight and overweight/obese individuals without diabetes (56.5 ± 7.7, 49.2 ± 7.2, 47.7 ± 7.4%, P < 0.004 for overall trends). Multiple regression analysis revealed that percentage of oxygen O2 recovery was a stronger predictor than VO2peak, BMI or age for fasting glucose and HbA1c.
Conclusions Patients with Type 2 diabetes have lower VO2peak and prolonged oxygen O2 recovery from peak exercise. However, only prolonged oxygen O2 recovery was associated with fasting glucose and HbA1c.
