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Paget disease of bone: diagnosis and indications for treatment

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journal contribution
posted on 2024-06-03, 12:55 authored by MA Kotowicz
BACKGROUND: Paget disease was first described in 1877 by Sir James Paget. It is a focal disorder of bone remodelling, involving increased bone resorption and formation. The aetiology is uncertain but both environmental and genetic factors are thought to be involved in pathogenesis. OBJECTIVE: This article outlines the clinical presentation, diagnosis and treatment of Paget disease. DISCUSSION: Paget disease is associated with musculoskeletal pain, significant disability and impaired quality of life. Complications include pathological fracture, arthritis in adjacent joints, hearing loss, other neurological complications, heart failure and, rarely, osteosarcoma. Recent clinical trial data has demonstrated histological and radiological improvements in bone of patients treated with bisphosphonates. There is little data evaluating the long term effect of therapy on the risk of complications, however, restoration of normal bony architecture offers the prospect that complications related to deformity and increased bone fragility might be reduced by effective therapy.

History

Journal

Australian family physician

Volume

33

Pagination

127-131

Location

East Melbourne, Vic.

Open access

  • Yes

ISSN

0300-8495

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2004, The Royal Australian College of General Practitioners

Issue

3

Publisher

Royal Australian College of General Practitioners

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