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Past physical activity and age-related macular degeneration: The Melbourne Collaborative Cohort Study

Version 2 2024-06-13, 16:07
Version 1 2016-10-10, 13:50
journal contribution
posted on 2024-06-13, 16:07 authored by MB McGuinness, A Karahalios, JA Simpson, RH Guymer, LD Robman, AM Hodge, E Cerin, GG Giles, RP Finger
BACKGROUND/AIMS: To assess the association between past physical activity and early, intermediate and late age-related macular degeneration (AMD) in a community-based cohort study in Melbourne, Australia. METHODS: Diet and lifestyle information was recorded at baseline (1990-1994) and total recreational activity was derived from walking, vigorous and non-vigorous exercise. At follow-up (2003-2007), digital macular photographs were graded for early, intermediate and late AMD. Data were analysed using multinomial logistic regression controlling for age, sex, smoking, region of descent, diet and alcohol. Effect modification by sex was investigated. RESULTS: Out of 20 816 participants, early, intermediate and late AMD were detected at follow-up in 4244 (21%), 2661 (13%) and 122 (0.6%) participants, respectively. No association was detected between past total recreational physical activity and early, intermediate or late AMD. Frequent (≥3 times/week) and less frequent (1-2 times/week) vigorous exercise were associated with lower odds of intermediate and late AMD in univariable models. After controlling for confounders, there was evidence of effect modification by sex and frequent vigorous exercise was associated with a 22% decrease in the odds of intermediate AMD (95% CI 4% to 36%) in women, but no association was found for men. CONCLUSIONS: Past frequent vigorous exercise may be inversely related to the presence of intermediate AMD in women. Further studies are needed to confirm whether physical activity and exercise have a protective effect for AMD.

History

Journal

British Journal of Ophthalmology

Volume

100

Pagination

1353-1358

Location

England

ISSN

0007-1161

eISSN

1468-2079

Language

English

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2016, BMJ

Issue

10

Publisher

BMJ PUBLISHING GROUP