owens-paternalobesity-2017.pdf (1.4 MB)
Paternal obesity modifies the effect of an antenatal lifestyle intervention in women who are overweight or obese on newborn anthropometry
journal contribution
posted on 2017-05-08, 00:00 authored by Jodie M Dodd, Lodewyk E Du Plessis, Andrea R Deussen, Rosalie M Grivell, Lisa N Yelland, Jennie Louise, Andrew J Mcphee, Jeffrey S Robinson, Julie OwensJulie OwensThe contribution of paternal obesity to pregnancy outcomes has been little described. Our aims were to determine whether the effect of an antenatal maternal dietary and lifestyle intervention among women who are overweight or obese on newborn adiposity, was modified by paternal obesity. We conducted a secondary analysis of a multicenter randomised trial. Pregnant women with BMI ≥25 kg/m2 received either Lifestyle Advice or Standard Care. Paternal anthropometric measures included height, weight, BMI; waist, hip, calf and mid-upper arm circumferences; biceps and calf skinfold thickness measurements (SFTM); and percentage body fat. Newborn anthropometric outcomes included length; weight; head, arm, abdominal, and chest circumferences; biceps, triceps, subscapular, suprailiac, thigh, and lateral abdominal wall SFTM; and percentage body fat. The effect of an antenatal maternal dietary and lifestyle intervention among women who were overweight or obese on neonatal anthropometric measures, was significantly modified by paternal BMI ≥35.0 kg/m2, with a significantly smaller infant triceps, suprailiac, and thigh SFTM, and percent fat mass, compared with that observed in offspring of lean fathers. Further research is required to determine whether our observed associations are causal, and whether paternal weight loss prior to conception is a potential strategy to reduce the intergenerational effects of obesity.
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Journal
Scientific reportsVolume
7Article number
1557Pagination
1 - 9Publisher
NatureLocation
London, Eng.Publisher DOI
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2045-2322Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2017, The Author(s)Usage metrics
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