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Paternal obesity modifies the effect of an antenatal lifestyle intervention in women who are overweight or obese on newborn anthropometry

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journal contribution
posted on 2017-05-08, 00:00 authored by Jodie M Dodd, Lodewyk E Du Plessis, Andrea R Deussen, Rosalie M Grivell, Lisa N Yelland, Jennie Louise, Andrew J Mcphee, Jeffrey S Robinson, Julie Owens
The contribution of paternal obesity to pregnancy outcomes has been little described. Our aims were to determine whether the effect of an antenatal maternal dietary and lifestyle intervention among women who are overweight or obese on newborn adiposity, was modified by paternal obesity. We conducted a secondary analysis of a multicenter randomised trial. Pregnant women with BMI ≥25 kg/m2 received either Lifestyle Advice or Standard Care. Paternal anthropometric measures included height, weight, BMI; waist, hip, calf and mid-upper arm circumferences; biceps and calf skinfold thickness measurements (SFTM); and percentage body fat. Newborn anthropometric outcomes included length; weight; head, arm, abdominal, and chest circumferences; biceps, triceps, subscapular, suprailiac, thigh, and lateral abdominal wall SFTM; and percentage body fat. The effect of an antenatal maternal dietary and lifestyle intervention among women who were overweight or obese on neonatal anthropometric measures, was significantly modified by paternal BMI ≥35.0 kg/m2, with a significantly smaller infant triceps, suprailiac, and thigh SFTM, and percent fat mass, compared with that observed in offspring of lean fathers. Further research is required to determine whether our observed associations are causal, and whether paternal weight loss prior to conception is a potential strategy to reduce the intergenerational effects of obesity.

History

Journal

Scientific reports

Volume

7

Article number

1557

Pagination

1 - 9

Publisher

Nature

Location

London, Eng.

eISSN

2045-2322

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2017, The Author(s)