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Peri-Operative Risk Factors Associated with Post-Operative Cognitive Dysfunction (POCD): An Umbrella Review of Meta-Analyses of Observational Studies

Version 5 2024-08-05, 02:28
Version 4 2024-08-02, 00:18
Version 3 2024-06-19, 17:46
Version 2 2024-06-02, 15:08
Version 1 2023-05-03, 22:56
journal contribution
posted on 2024-08-05, 02:28 authored by N Travica, Mojtaba Lotfaliany Abrand AbadiMojtaba Lotfaliany Abrand Abadi, A Marriott, SA Safavynia, Melissa LaneMelissa Lane, Laura GrayLaura Gray, N Veronese, Michael BerkMichael Berk, David SkvarcDavid Skvarc, Hajara AslamHajara Aslam, Elizabeth GamageElizabeth Gamage, M Formica, K Bishop, Wolf MarxWolf Marx
This umbrella review aimed to systematically identify the peri-operative risk factors associated with post-operative cognitive dysfunction (POCD) using meta-analyses of observational studies. To date, no review has synthesised nor assessed the strength of the available evidence examining risk factors for POCD. Database searches from journal inception to December 2022 consisted of systematic reviews with meta-analyses that included observational studies examining pre-, intra- and post-operative risk factors for POCD. A total of 330 papers were initially screened. Eleven meta-analyses were included in this umbrella review, which consisted of 73 risk factors in a total population of 67,622 participants. Most pertained to pre-operative risk factors (74%) that were predominantly examined using prospective designs and in cardiac-related surgeries (71%). Overall, 31 of the 73 factors (42%) were associated with a higher risk of POCD. However, there was no convincing (class I) or highly suggestive (class II) evidence for associations between risk factors and POCD, and suggestive evidence (class III) was limited to two risk factors (pre-operative age and pre-operative diabetes). Given that the overall strength of the evidence is limited, further large-scale studies that examine risk factors across various surgery types are recommended.

History

Journal

Journal of Clinical Medicine

Volume

12

Article number

ARTN 1610

Pagination

1-20

Location

Switzerland

ISSN

2077-0383

eISSN

2077-0383

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Issue

4

Publisher

MDPI