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Perinatal growth and plasma GH profiles in adolescent and adult sheep

Version 2 2024-06-05, 02:07
Version 1 2019-01-16, 15:10
journal contribution
posted on 2024-06-05, 02:07 authored by KL Gatford, IJ Clarke, MJ De Blasio, IC McMillen, J S Robinson, Julie OwensJulie Owens
Poor prenatal growth is associated with limited evidence of GH deficiency in adult humans, which may contribute to their increased risk of cardiovascular and metabolic disease. We therefore examined the effects of placental restriction of fetal growth (PR) on size at birth, neonatal fractional growth rate (FGR) and the circulating GH profile in adolescent and young adult sheep of both sexes. Moderate or severe PR decreased birth size and increased neonatal FGR of weight, crown-rump length and abdominal circumference. In adolescent males, mean and baseline GH concentrations correlated negatively and independently with birth weight and FGR of weight, and mean GH concentrations correlated negatively with current weight. In young adult males, mean GH concentrations correlated negatively and independently with birth shoulder height and FGR of shoulder height whilst, in young adult females, these correlations were positive. This suggests that restricted fetal growth and reduced neonatal growth rate in sheep are followed by elevated circulating GH in adolescent and adult males, but GH deficiency or increased GH clearance in adult females.

History

Journal

Journal of endocrinology

Volume

173

Pagination

151-159

Location

Bradley Stok, Eng.

ISSN

0022-0795

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2002, Society for Endocrinology

Issue

1

Publisher

Bioscientifica