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Perinatal microbial exposure may influence aortic intima-media thickness in early infancy

journal contribution
posted on 2017-02-01, 00:00 authored by Kate MccloskeyKate Mccloskey, Peter VuillerminPeter Vuillermin, J B Carlin, M Cheung, M R Skilton, M L K Tang, K Allen, G L Gilbert, S Ranganathan, Fiona Collier, T Dwyer, A-L Ponsonby, D Burgner
BACKGROUND: The maternal and infant microbiome may influence infant cardiovascular risk through immune programming. The maternal vagino-enteric microbiome is often sampled for group B streptococcus (GBS) colonization during pregnancy. Our aim was to investigate the association between maternal GBS colonization, intrapartum antibiotics, antenatal pet exposure and infant aortic intima-media thickness (aIMT), an intermediate vascular phenotype, and whether this association varied by mode of delivery. METHODS: The Barwon Infant Study is a population-derived pre-birth cohort. Perinatal data were collected on participants. Women were tested for vagino-enteric group B streptococcus (GBS) colonization during third trimester. Six-week infant aIMT was measured by trans-abdominal ultrasound. Adjustment for confounders included maternal age, pre-pregnancy body mass index (BMI), smoking, socioeconomic status, gestational diabetes, length of gestation, infant sex, birthweight and aortic internal diameter. RESULTS: Data were available on 835 mother-infant pairs. Of these, 574 (69%) women delivered vaginally; of those, 129 (22%) were GBS-colonized; and of these women, 111 (86%) received prophylactic intrapartum antibiotics. An association between maternal GBS colonization and infant aIMT was observed among those delivered vaginally (β = 19.5 µm, 95% CI 9.5, 29.4;P < 0.0001) but not by Caesarean section (Pfor interaction = 0.02). A similar pattern was seen for intrapartum antibiotics. There was a negative association between antenatal pet exposure and aIMT observed in those delivered vaginally. CONCLUSION: Maternal GBS colonization and intrapartum antibiotics were associated with increased infant aIMT in those delivered vaginally, whereas antenatal pet exposure was associated with decreased aIMT. These data suggest that differences in early life microbial experience may contribute to an increased cardiovascular risk.

History

Journal

International journal of epidemiology

Volume

46

Issue

1

Pagination

209 - 218

Publisher

Oxford University Press

Location

Oxford, Eng.

ISSN

0300-5771

eISSN

1464-3685

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2016, The Authors