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Peripheral quantitative computed tomography in children and adolescents : the 2007 ISCD pediatric official positions

journal contribution
posted on 2008-01-01, 00:00 authored by B Zemel, Shona Bass, T Binkley, Gaele Ducher, H Macdonald, H McKay, L Moyer-Mileur, J Shepherd, B Specker, K Ward, D Hans
Peripheral quantitative computed tomography (pQCT) has mainly been used as a research tool in children. To evaluate the clinical utility of pQCT and formulate recommendations for its use in children, the International Society
of Clinical Densitometry (ISCD) convened a task force to review the literature and propose areas of consensus and future research. The types of pQCT technology available, the clinical application of pQCT for bone health assessment in children, the important elements to be included in a pQCT report, and quality control monitoring techniques were evaluated. The review revealed a lack of standardization of pQCT techniques, and a paucity of data regarding differences between pQCT manufacturers, models and software versions and their impact in pediatric assessment. Measurement sites varied across studies. Adequate reference data, a critical element for interpretation of pQCT results, were entirely lacking, although some comparative data on healthy children were available. The elements of the
pQCT clinical report and quality control procedures are similar to those recommended for dual-energy X-ray absorptiometry. Future research is needed to establish evidence-based criteria for the selection of the measurement site, scan acquisition and analysis parameters, and outcome measures. Reference data that sufficiently characterize the normal range of variability in the population also need to be established.

History

Journal

Journal of clinical densitometry

Volume

11

Issue

1

Pagination

59 - 74

Publisher

Elsevier B.V.

Location

Amsterdam, The Netherlands

ISSN

1094-6950

eISSN

1559-0747

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2008, The International Society for Clinical Densitometry