File(s) under permanent embargo

Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats

journal contribution
posted on 2001-10-01, 00:00 authored by A Hamlin, K Buller, Trevor Day, P Osborne
This study examined if brain pathways in morphine-dependent rats are activated by opioid withdrawal precipitated outside the central nervous system. Withdrawal precipitated with a peripherally acting quaternary opioid antagonist (naloxone methiodide) increased Fos expression but caused a more restricted pattern of neuronal activation than systemic withdrawal (precipitated with naloxone which enters the brain). There was no effect on locus coeruleus and significantly smaller increases in Fos neurons were produced in most other areas. However in the ventrolateral medulla (A1/C1 catecholamine neurons), nucleus of the solitary tract (A2/C2 catecholamine neurons), lateral parabrachial nucleus, supramamillary nucleus, bed nucleus of the stria terminalis, accumbens core and medial prefrontal cortex no differences in the withdrawal treatments were detected. We have shown that peripheral opioid withdrawal can affect central nervous system pathways.

History

Journal

Neuropharmacology

Volume

41

Issue

5

Pagination

574 - 581

Publisher

Pergamon

Location

Oxford, England

ISSN

0028-3908

Language

eng

Publication classification

C3.1 Non-refereed articles in a professional journal

Copyright notice

2001, Elsevier Science