Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (PERM1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells
journal contributionposted on 2013-08-30, 00:00 authored by Y Cho, B C Hazen, Aaron RussellAaron Russell, A Kralli
Background: The regulatory mechanisms that control skeletal muscle bioenergetics are not fully understood. Results: The muscle-specific protein Perm1 is induced by exercise and exercise-activated regulators and controls the expression of energy homeostasis genes. Conclusion: Perm1 is a regulator of mitochondrial oxidative capacity and bioenergetics. Significance: Novel muscle regulators of bioenergetics may facilitate approaches for preserving/enhancing muscle function. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
JournalJournal of Biological Chemistry
Pagination25207 - 25218
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Publication classificationC Journal article; C1.1 Refereed article in a scholarly journal
Copyright notice2013, The American Society for Biochemistry and Molecular Biology, Inc.
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Science & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyAMYOTROPHIC-LATERAL-SCLEROSISALPHA ERR-ALPHAMITOCHONDRIAL BIOGENESISNUCLEAR RECEPTORGENE-EXPRESSIONFIBER-TYPETRANSCRIPTIONAL CONTROLENERGY-METABOLISMPGC-1 COACTIVATORSCREATINE-KINASEBioenergeticsEnergy MetabolismEstrogen-related ReceptorNuclear ReceptorsPGC-1αSkeletal MuscleTranscription RegulationAgingAnimalsBase SequenceCell LineGene SilencingHumansLipid MetabolismMiceMolecular Sequence DataMuscle ContractionMuscle ProteinsMuscular AtrophyMuscular DiseasesMyoblasts, SkeletalOrgan SpecificityPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaTranscription Factors