Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (PERM1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells

Background: The regulatory mechanisms that control skeletal muscle bioenergetics are not fully understood. Results: The muscle-specific protein Perm1 is induced by exercise and exercise-activated regulators and controls the expression of energy homeostasis genes. Conclusion: Perm1 is a regulator of mitochondrial oxidative capacity and bioenergetics. Significance: Novel muscle regulators of bioenergetics may facilitate approaches for preserving/enhancing muscle function. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.