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Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (PERM1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells

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journal contribution
posted on 30.08.2013, 00:00 authored by Y Cho, B C Hazen, Aaron RussellAaron Russell, A Kralli
Background: The regulatory mechanisms that control skeletal muscle bioenergetics are not fully understood. Results: The muscle-specific protein Perm1 is induced by exercise and exercise-activated regulators and controls the expression of energy homeostasis genes. Conclusion: Perm1 is a regulator of mitochondrial oxidative capacity and bioenergetics. Significance: Novel muscle regulators of bioenergetics may facilitate approaches for preserving/enhancing muscle function. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

History

Journal

Journal of Biological Chemistry

Volume

288

Issue

35

Pagination

25207 - 25218

ISSN

0021-9258

eISSN

1083-351X

Publication classification

C Journal article; C1.1 Refereed article in a scholarly journal

Copyright notice

2013, The American Society for Biochemistry and Molecular Biology, Inc.