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Persistent organic pollutants and diabetes: a review of the epidemiological evidence
journal contribution
posted on 2014-02-01, 00:00 authored by D J Magliano, Venurs LohVenurs Loh, J L Harding, J Botton, J E ShawThe prevalence of diabetes and obesity has increased rapidly over the last few decades in both developed and developing countries. While it is intuitively appealing to suggest that lifestyle risk factors such as decreased physical activity and adoption of poor diets can explain much of the increase, the evidence to support this is poor. Given this, there has been an impetus to look more widely than traditional lifestyle and biomedical risk factors, especially those risk factors, which arise from the environment. Since the industrial revolution, there has been an introduction of many chemicals into our environment, which have now become environmental pollutants. There has been growing interest in one key class of environmental pollutants known as persistent organic pollutants (POPs) and their potential role in the development of diabetes. This review will summarise and appraise the current epidemiological evidence relating POPs to diabetes and highlight gaps and flaws in this evidence.
History
Journal
Diabetes & metabolismVolume
40Issue
1Pagination
1 - 14Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
eISSN
1878-1780Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2013, Elsevier Masson SASUsage metrics
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No categories selectedKeywords
DiabetesDioxinPersistent organic pollutantsPolychlorinated biphenylsAdipose TissueAir Pollutants, OccupationalDiabetes Mellitus, Type 2Environmental ExposureEnvironmental PollutantsEpidemiological MonitoringFemaleGlucose Transport Proteins, FacilitativeHerbicidesHumansHydrocarbons, ChlorinatedInsulinLiverMalePancreasPolychlorinated DibenzodioxinsPrevalenceProtein BindingRisk FactorsScience & TechnologyLife Sciences & BiomedicineEndocrinology & Metabolism2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN CAUSES REDUCTIONPOLYCHLORINATED-BIPHENYLSSERUM CONCENTRATIONSORGANOCHLORINE PESTICIDESNATIONAL-HEALTHEXPOSUREGLUCOSEASSOCIATIONVETERANS
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