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Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia

journal contribution
posted on 17.07.2006, 00:00 authored by Y Kawakubo, K Kasai, N Kudo, Mark RogersMark Rogers, K Nakagome, K Itoh, N Kato
Deficits in auditory sensory memory at the electrophysiological level as indexed by mismatch negativity and those in auditory verbal memory at the neuropsychological level have been independently demonstrated in previous studies of schizophrenia. We predicted a specific association between these indices in schizophrenia. Mismatch negativities elicited by change in tone duration and phoneme duration were recorded in 23 schizophrenia patients, who were also evaluated for auditory verbal memory and executive function. Lower amplitude of mismatch negativity under the phoneme-duration condition was significantly associated with worse verbal memory. Phoneme-duration mismatch negativity was not correlated with executive function, nor was tone-duration mismatch negativity correlated with verbal memory. These results suggest that electrophysiological auditory sensory memory dysfunction underlies the basis for neuropsychological auditory verbal memory deficits in schizophrenia.

History

Journal

Neuroreport

Volume

17

Issue

10

Pagination

1043 - 1046

Publisher

Lippincott Williams & Wilkins

Location

Philadelphia, Pa.

ISSN

0959-4965

eISSN

1473-558X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2006, Lippincott Williams & Wilkins