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Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?

journal contribution
posted on 2007-04-01, 00:00 authored by Mark GuthridgeMark Guthridge, A F Lopez
Cytokines and growth factors exert multiple biological activities through their ability to engage and activate specific receptors displayed on the surface of cells. How these receptors are able to differentially (and sometimes independently) regulate cell survival, proliferation, differentiation and activation to control quite specific and distinct cellular outcomes is unclear. Similarly, how a single growth factor or cytokine receptor can specify alternate cellular responses and control very different cellular fates is also not known. We present a new mechanism by which cytokines and growth factors are able to control these pleiotropic responses.

History

Journal

BIOCHEMICAL SOCIETY TRANSACTIONS

Volume

35

Issue

2

Pagination

250 - 252

Publisher

PORTLAND PRESS LTD

Location

Bath, ENGLAND

ISSN

0300-5127

eISSN

1470-8752

Language

English

Publication classification

CN.1 Other journal article

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