owens-placentalrestriction-2007.pdf (308.91 kB)
Placental restriction of fetal growth increases insulin action, growth, and adiposity in the young lamb
journal contribution
posted on 2007-03-01, 00:00 authored by Miles J De Blasio, Kathryn L Gatford, I Caroline McMillen, Jeffrey S Robinson, Julie OwensJulie OwensMost children who are short or light at birth due to intrauterine growth restriction (IUGR) exhibit accelerated growth in infancy, termed "catch-up" growth, which together with IUGR, predicts increased risk of type 2 diabetes and obesity later in life. Placental restriction (PR) in sheep reduces size at birth, and also causes catch-up growth and increased adiposity at 6 wk of age. The physiological mechanisms responsible for catch-up growth after IUGR and its links to these adverse sequelae are unknown. Because insulin is a major anabolic hormone of infancy and its actions are commonly perturbed in these related disorders, we hypothesized that restriction of fetal growth would alter insulin secretion and sensitivity in the juvenile sheep at 1 month, which would be related to their altered growth and adiposity. We show that PR impairs glucose-stimulated insulin production, but not fasting insulin abundance or production in the young sheep. However, PR increases insulin sensitivity of circulating free fatty acids (FFAs), and insulin disposition indices for glucose and FFAs. Catch-up growth is predicted by the insulin disposition indices for amino acids and FFAs, and adiposity by that for FFAs. This suggests that catch-up growth and early-onset visceral obesity after IUGR may have a common underlying cause, that of increased insulin action due primarily to enhanced insulin sensitivity, which could account in part for their links to adverse metabolic and related outcomes in later life.
History
Journal
EndocrinologyVolume
148Issue
3Pagination
1350 - 1358Publisher
Oxford University PressLocation
Oxford, Eng.Publisher DOI
ISSN
0013-7227Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2007, The Endocrine SocietyUsage metrics
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No categories selectedKeywords
AdiposityAnimalsAnimals, NewbornBirth WeightBlood GlucoseBody SizeFemaleFetal Growth RetardationGlucose Tolerance TestInsulinInsulin ResistanceMalePregnancyPregnancy, AnimalSheepScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismFOR-GESTATIONAL-AGECATCH-UP GROWTHCORONARY-HEART-DISEASEBIRTH-WEIGHTSHEEP FETUSFACTOR-ISECRETIONHORMONEOBESITYHYPERINSULINEMIA
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