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Placental restriction of fetal growth reduces cutaneous responses to antigen after sensitization in sheep
journal contribution
posted on 2014-04-01, 00:00 authored by Amy L Wooldridge, Robert J Bischof, Els N Meeusen, Hong Liu, Gary K Heinemann, Damien S Hunter, Lynne C Giles, Karen L Kind, Julie OwensJulie Owens, Vicki L Clifton, Kathryn L GatfordPrenatal and early childhood exposures are implicated as causes of allergy, but the effects of intrauterine growth restriction on immune function and allergy are poorly defined. We therefore evaluated effects of experimental restriction of fetal growth on immune function and allergic sensitization in adolescent sheep. Immune function (circulating total red and white blood cells, neutrophils, lymphocytes, monocytes, eosinophils, and basophils, and the antibody response to Clostridial vaccination) and responses to house dust mite (HDM) allergen and ovalbumin (OVA) antigen sensitization (specific total Ig, IgG1, and IgE antibodies, and cutaneous hypersensitivity) were investigated in adolescent sheep from placentally restricted (PR, n = 23) and control (n = 40) pregnancies. Increases in circulating HDM-specific IgE (P = 0.007) and OVA-specific IgE (P = 0.038) were greater in PR than control progeny. PR did not alter total Ig, IgG1, or IgM responses to either antigen. PR increased OVA-specific but not HDM-specific IgA responses in females only (P = 0.023). Multiple birth increased Ig responses to OVA in a sex-specific manner. PR decreased the proportion of positive cutaneous hypersensitivity responders to OVA at 24 h (P = 0.030) but had no effect on cutaneous responses to HDM. Acute wheal responses to intradermal histamine correlated positively with birth weight in singletons (P = 0.023). Intrauterine growth restriction may suppress inflammatory responses in skin downstream of IgE induction, without impairment in antibody responses to a nonpolysaccharide vaccine. Discord between cutaneous and IgE responses following sensitization suggests new mechanisms for prenatal allergy programming.
History
Journal
American journal of physiology: regularity, integrative and comparative physiologyVolume
306Issue
7Pagination
R441 - R446Publisher
American Physiological SocietyLocation
Bethesda, Md.Publisher DOI
eISSN
1522-1490Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2014 the American Physiological SocietyUsage metrics
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No categories selectedKeywords
allergyanimal modeldevelopmental programmingintrauterine growth restrictionsheepAge FactorsAnimalsAntibodies, BacterialAntigensBacterial VaccinesBirth WeightClostridiumDisease Models, AnimalFemaleFetal Growth RetardationGestational AgeHistamineHypersensitivity, DelayedHypersensitivity, ImmediateImmunizationImmunoglobulin EImmunoglobulin GImmunoglobulin MInsect ProteinsMaleOvalbuminPregnancyPyroglyphidaeSkinSkin TestsScience & TechnologyLife Sciences & BiomedicinePhysiologyFOR-GESTATIONAL-AGELOW-BIRTH-WEIGHTHOUSE-DUST MITEPOSTNATAL ENVIRONMENTSPREGNANCY OUTCOMESMETABOLIC SYNDROMEIGE CONCENTRATIONADULTS BORNASTHMACHILDREN
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