berk-plasmalevels-2017.pdf (624.83 kB)
Plasma levels of tumor necrosis factor superfamily molecules are increased in bipolar disorder
journal contribution
posted on 2017-01-01, 00:00 authored by I G Barbosa, G N Vaz, N P Rocha, R Machado-Vieira, M R D Ventura, R B Huguet, M E Bauer, Michael BerkMichael Berk, A L TeixeiraObjective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA. Results: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. Conclusion: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
History
Journal
clinical psychopharmacology and neuroscienceVolume
15Issue
3Pagination
269 - 275Publisher
Korean College of NeuropsychopharmacologyLocation
Seoul, South KoreaPublisher DOI
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ISSN
1738-1088Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2018, Korean College of NeuropsychopharmacologyUsage metrics
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