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Polypropylene-nanodiamond composite for hernia mesh

Version 2 2024-06-05, 11:05
Version 1 2021-06-11, 14:24
journal contribution
posted on 2024-06-05, 11:05 authored by S Houshyar, A Sarker, A Jadhav, GS Kumar, A Bhattacharyya, R Nayak, RA Shanks, T Saha, A Rifai, R Padhye, K Fox
Commercial hernia mesh is commonly made from polypropylene (PP), due to its inertness, biocompatibility, physical properties, ease of processing and versatility for conversion into flexible shape. However, reportedly hernia mesh prepared from PP experienced issues such as diminished long-term strength, foreign body rejection, lack of biocompatibility and high adhesion to the abdomen wall. Infiltration of the mesh by soft tissue (called remodeling) results in an integration of mesh into the body, leading to a rapid reduction in mesh mechanical properties and potential infection. Here, this study addresses these issues through the incorporation of nanodiamond (ND) into PP filament and coating on the surface of plasma-treated PP-ND mesh. The results show that the dynamic modulus of the PP-ND mesh increased significantly, without compromising its flexibility. Coating PP-ND mesh with hydroxylated ND led to a reduction in nonspecific protein adsorption onto the surface of nanocomposite, which is an important characteristic for hernia mesh to prevent foreign body reaction, attachment of mesh to the abdominal wall and nearby organs. In-vitro study with mammalian cells shows that coated PP-ND mesh with functionalized ND exhibits a significant increase in the number of adhered cells with more elongated morphology in comparison with other PP meshes, due to the better hydrophilicity. Therefore, the ND coated nanocomposite mesh can be a promising candidate for hernia repair in the future; however, more investigation is required.

History

Journal

Materials Science and Engineering C

Volume

111

Article number

ARTN 110780

Pagination

1 - 10

Location

Netherlands

ISSN

0928-4931

eISSN

1873-0191

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Publisher

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