Deakin University
Browse

File(s) under permanent embargo

Porous and electrically conductive polypyrrole−poly(vinyl alcohol) composite and its applications as a biomaterial

journal contribution
posted on 2005-01-01, 00:00 authored by Yali Li, K G Neoh, L Cen, E T Kang
Bulk modification of polypyrrole (PPY) with poly(vinyl alcohol) (PVA) was carried out by the electropolymerization of pyrrole in the presence of PVA in the reaction solution, with tetraethylammonium perchlorate (TEAP) as the electrolyte. The surface morphology of the as-synthesized PPY-TEAP-PVA film was investigated using scanning electron microscopy, and the film was further characterized using X-ray photoelectron spectroscopy, electrical conductivity, the water contact angle, and BET surface area measurements. The PPY-TEAP-PVA composite is electrically conductive, hydrophilic, and microporous with a high surface area. Its potential as a biomaterial was investigated with respect to its blood compatibility and function as a substrate for biosensor fabrication and cell culture. The presence of PVA in the film attenuates blood protein adsorption, and the porous nature of the PPY-TEAP-PVA film results in a 10-fold increase in the amount of glucose oxidase covalently immobilized on the film over that on a nonporous PPY film. PC12 cell attachment and growth on the PPY-TEAP-PVA film was also shown to be enhanced compared with that on tissue culture polystyrene. The attached cells proliferated and formed a monolayer on the film surface after 48 h of seeding.

History

Journal

Langmuir

Volume

21

Issue

23

Pagination

10702 - 10709

Publisher

American Chemical Society

Location

Washington, D.C.

ISSN

0743-7463

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2005, American Chemical Society