Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with significant clinical, social and financial impacts for patients and their communities. The underlying pathophysiology is becoming increasingly understood, with the role of neuroinflammation and oxidative stress secondary to surgery and anaesthesia strongly implicated. This review aims to describe the putative mechanisms by which surgery-induced inflammation produces cognitive sequelae, with a focus on identifying potential novel therapies based upon their ability to modify these pathways.
History
Journal
Neuroscience and biobehavioral reviews
Volume
84
Pagination
116-133
Location
Amsterdam, The Netherlands
ISSN
0149-7634
eISSN
1873-7528
Language
eng
Publication classification
C Journal article, C1 Refereed article in a scholarly journal