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Post-prandial remnant lipids impair arterial compliance

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journal contribution
posted on 2001-06-01, 00:00 authored by P Nestel, H Shige, Sylvia Pomeroy, M Cehun, J Chin-Dusting
OBJECTIVES
We sought to examine the effects of plasma lipids, especially in remnants after a fat meal, on systemic arterial compliance (SAC), a newly recognized cardiovascular risk factor.
BACKGROUND
Post-prandial remnants correlate with coronary heart disease events through mechanisms that may include vascular dysfunction, although the effect on SAC has not been studied.
METHODS
Systemic arterial compliance was measured non-invasively over 6 h after a fat meal in 16 subjects with varying plasma triglyceride levels. Changes were related to rises in plasma lipids and remnant lipids. Systemic arterial compliance was measured in 20 subjects after a control low-fat meal.
RESULTS
The fat meal induced increments in plasma triglyceride and remnant cholesterol and triglyceride (respectively +54%, 50% and 290% at 3 h, analysis of variance <0.001). Systemic arterial compliance fell at 3 h and 6 h by 25% and 27% (analysis of variance <0.001). Baseline SAC correlated significantly with all lipid concentrations at 0, 3 h and 6 h, but only with triglyceride on stepwise regression analysis. The SAC response to the low-fat meal was very small and not significant.
CONCLUSIONS
This is the first demonstration of SAC becoming impaired after a fat meal. Remnant lipids and plasma total triglyceride appeared to contribute to the fall in SAC.

History

Journal

Journal of the American College of Cardiology

Volume

37

Issue

7

Pagination

1929 - 1935

Publisher

Elsevier Inc.

Location

San Diego, Calif.

ISSN

0735-1097

eISSN

1558-3597

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2001, American College of Cardiology

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