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Post-translational lipid modifications in Plasmodium parasites
journal contributionposted on 2023-02-08, 01:21 authored by Natalie CounihanNatalie Counihan, HC Chernih, Tania De Koning-WardTania De Koning-Ward
Most eukaryotic proteins undergo post-translational modifications (PTMs) that significantly alter protein properties, regulate diverse cellular processes and increase proteome complexity. Among these PTMs, lipidation plays a unique and key role in subcellular trafficking, signalling and membrane association of proteins through altering substrate function, and hydrophobicity via the addition and removal of lipid groups. Three prevalent classes of lipid modifications in Plasmodium parasites include prenylation, myristoylation, and palmitoylation that are important for regulating parasite-specific molecular processes. The enzymes that catalyse these lipid attachments have also been explored as potential drug targets for antimalarial development. In this review, we discuss these lipidation processes in Plasmodium spp. and the methodologies that have been used to identify these modifications in the deadliest species of malaria parasite, Plasmodium falciparum. We also discuss the development status of inhibitors that block these pathways.
JournalCurrent Opinion in Microbiology
LocationAmsterdam, The Netherlands
Publication classificationC1 Refereed article in a scholarly journal
ACYLATIONFALCIPARUMFARNESYLTRANSFERASEIDENTIFICATIONLife Sciences & BiomedicineMALARIAMicrobiologyN-MYRISTOYLTRANSFERASE INHIBITORSPRENYLATIONPROTEIN S-PALMITOYLATIONREVEALSScience & TechnologyTRANSFERASESAnimalsLipidsParasitesPlasmodiumPlasmodium falciparumProtein Processing, Post-TranslationalProtozoan ProteinsRare DiseasesOrphan DrugVector-Borne DiseasesMalariaInfectious Diseases2 Aetiology2.2 Factors relating to the physical environmentInfection3 Good Health and Well BeingMicrobiologyMedical Microbiology not elsewhere classified