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Potent new cell adhesion inhibitory compounds from the root of Trichilia rubra

journal contribution
posted on 1994-01-01, 00:00 authored by L L Musza, L M Killar, P Speight, S McElhiney, C J Barrow, A M Gillum, R Cooper
A series of seco-limonoids, with uncommon hemi ortho ester A-rings, was isolated from the root of Trichilia rubra. Their structures were determined by extensive spectroscopic studies. The five new and two previously known compounds were all found to be potent inhibitors of LFA-1:ICAM-1 mediated cell adhesion.

History

Journal

Tetrahedron

Volume

50

Issue

39

Pagination

11369 - 11378

Publisher

Elsevier Science

Location

Amsterdam, The Netherlands

ISSN

0040-4020

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1994, Elsevier Science