kim-prefrontalamygdala-2017.pdf (1.43 MB)
Prefrontal-amygdala connectivity and state anxiety during fear extinction recall in adolescents
journal contribution
posted on 2017-12-04, 00:00 authored by D E Ganella, M E A Barendse, Jee Hyun KimJee Hyun Kim, S WhittleWhile deficits in fear extinction recall have been suggested to underlie vulnerability to anxiety disorders in adolescents, the neurobiology of these deficits remain underexplored. Here we investigate the functional connectivity (FC) of the ventromedial prefrontal cortex (vmPFC) and dorsolateral PFC (dlPFC) underlying extinction recall in healthy adolescents, and assess associations between FC and state/trait anxiety. Adolescents (17) and adults (14, for comparison) completed a fear-learning paradigm involving extinction and extinction recall during a functional magnetic resonance imaging session, in which skin conductance response (SCR) was recorded. Psychophysiological interaction analyses revealed that during extinction recall there was significant negative connectivity between the vmPFC and amygdala in adults, but not adolescents. vmPFC-amygdala connectivity was positively correlated with SCR. Adolescents showed significant negative FC between the dlPFC and the left and right hippocampus, and the amygdala, which was positively correlated with state anxiety. Recall was also associated with negative connectivity between the dlPFC and thalamus, posterior cingulate cortex, fusiform gyrus, and pallidum in adolescents. These results demonstrate that fear extinction recall in healthy adolescents is associated with FC between prefrontal and limbic brain regions, and suggest that alterations in connectivity may be associated with vulnerability to anxiety in adolescence.
History
Journal
Frontiers in Human NeuroscienceVolume
11Article number
587Pagination
1 - 9Publisher
Frontiers Research FoundationLocation
Lausanne, SwitzerlandPublisher DOI
Link to full text
eISSN
1662-5161Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
Science & TechnologySocial SciencesLife Sciences & BiomedicineNeurosciencesPsychologyNeurosciences & Neurologyadolescenceprefrontal cortexamygdalaextinctionconnectivityanxietyCONDITIONED FEARLIFETIME PREVALENCEDECLARATIVE MEMORYMENTAL-DISORDERSBRAIN MECHANISMSNEGATIVE AFFECTCORTEXHIPPOCAMPUSTHREATRATS
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC