Prenatal high salt diet increases blood pressure and salt retention in the spontaneously hypertensive rat.
Version 2 2024-06-13, 09:10Version 2 2024-06-13, 09:10
Version 1 2015-08-14, 12:18Version 1 2015-08-14, 12:18
journal contribution
posted on 2024-06-13, 09:10authored byRD Nicolantonio, S Spargo, TO Morgan
1. An examination was made of the effect of prenatal, high salt (5% w/w) and low salt (0.1% w/w) diet on the blood pressure and ability to excrete a salt load of mature spontaneously hypertensive rats (SHR) of the Okamoto strain maintained on normal salt (0.8% w/w) diet after weaning. 2. Prenatal high salt diet resulted in a significant exacerbation of the hypertension of 4 month old SHR when compared with animals given prenatal low salt diet. 3. Three month old SHR given prenatal, high salt diet exhibited a significantly reduced Na+ excretion following a single, oral salt load (150 mmol/l, 1% bodyweight) when compared with the low salt group. 4. Thus, prenatal, high salt diet may influence body fluid homeostasis in genetically susceptible individuals later in life.
History
Journal
Clinical and Experimental Pharmacology and Physiology