Deakin University
Browse

File(s) under permanent embargo

Preparation, characterization and in vitro study of liposomal curcumin powder by cost effective nanofiber weaving technology

Version 2 2024-06-05, 09:35
Version 1 2018-07-12, 16:04
journal contribution
posted on 2024-06-05, 09:35 authored by S Gopi, A Amalraj, J Jacob, N Kalarikkal, S Thomas, Q Guo
Liposomes can facilitate the incorporation of both hydrophilic and hydrophobic molecules into nutraceutical products through a constructive impact on their stability, drug delivery and bioavailability. Liposomal products are mostly available in a liquid/suspension form, because phospholipids are stabilized by a water-in-oil emulsion as a vehicle-like compartment for encapsulation. Although, they have low stability due to the randomness of bilayer folding of phospholipids in the presence of water typically leading to non-uniform formation in both shape and size. In this study, a powder form of the phospholipid vehicle was formulated with a nanofiber fabrication via nanofiber weaving (NFW) technology by high pressure homogenization and removal of water through a spray drying process. We designed and developed a liposomal curcumin powder (LCP) based on NFW technology to enhance the bioavailability of curcumin and improve the stability of LCP. The encapsulation efficiency, loading capacity, in vitro release and DPPH activity revealed that LCP could be a promising drug delivery system for curcumin due to the use of NFW technology.

History

Journal

New journal of chemistry

Volume

42

Pagination

5117-5127

Location

Cambridge, Eng.

ISSN

1144-0546

eISSN

1369-9261

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, The Royal Society of Chemistry and the Centre National de la Recherche Scientifique

Issue

7

Publisher

Royal Society of Chemistry

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC