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Preparation of monodisperse aqueous microspheres containing high concentration of L-ascorbic acid by microchannel emulsification

Version 2 2024-06-06, 12:46
Version 1 2016-09-09, 13:47
journal contribution
posted on 2024-06-06, 12:46 authored by N Khalid, I Kobayashi, MA Neves, K Uemura, M Nakajima, H Nabetani
Monodisperse aqueous microspheres containing high concentrations of l-ascorbic acid with different concentrations of sodium alginate (Na-ALG) and magnesium sulfate (MgSO4) were prepared by using microchannel emulsification (MCE). The continuous phase was water-saturated decane containing a 5% (w/w) hydrophobic emulsifier. The flow rate of the continuous phase was maintained at 10 mL h(-1), whereas the pressure applied to the disperse phase was varied between 3 and 25 kPa. The disperse phase optimized for successfully generating aqueous microspheres included 2% (w/w) Na-ALG and 1% (w/w) MgSO4. At a higher MgSO4 concentration, the generated microspheres resulted in coalescence and subsequent bursting. At a lower MgSO4 concentration, unstable and polydisperse microspheres were obtained. The aqueous microspheres generated from the MCs under optimized conditions had a mean particle diameter (dav) of 14-16 µm and a coefficient of variation (CV) of less than 8% at the disperse phase pressures of 5-15 kPa.

History

Journal

Journal of microencapsulation

Volume

32

Pagination

570-577

Location

London, Eng.

ISSN

0265-2048

eISSN

1464-5246

Language

eng

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2015, Informa UK

Issue

6

Publisher

Informa Healthcare