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Prepsychotic phase of schizophrenia and related disorders: Recent progress and future opportunities

Version 2 2024-06-05, 11:29
Version 1 2021-05-13, 15:08
journal contribution
posted on 2024-06-05, 11:29 authored by LJ Phillips, PD McGorry, Alison YungAlison Yung, TH McGlashan, B Cornblatt, J Klosterkötter
BackgroundClinical and research focus has recently shifted from established psychotic disorders to first-episode psychosis and the prepsychotic phase of illness.AimsTo describe the principles, progress and dilemmas associated with the prospective detection, engagement and treatment of young people at risk of developing a psychotic disorder.MethodStrategies to identify young people at heightened risk of a psychotic disorder are described. Preventive interventions and results of their evaluation are provided.ResultsWell-validated criteria for identifying young people at heightened risk of psychosis have been developed, evidence of the efficacy of various psychological and pharmacological interventions in preventing progression has accumulated and progress towards the identification of clinical and neurobiological predictors of transition to acute psychosis has been made.ConclusionsThe detection, monitoring and treatment of young people in the prepsychotic phase is a growth area in psychiatry. The ethical considerations about treatment options, treatment of minors and provision of information about risk status must be treated with sensitivity if the potential benefit to many young people and their families is to be realised.

History

Journal

British Journal of Psychiatry

Volume

187

Pagination

S33-S44

Location

Copenhagen, DENMARK

ISSN

0007-1250

eISSN

1472-1465

Language

English

Publication classification

E3.1 Extract of paper

Issue

SUPPL. 48

Publisher

CAMBRIDGE UNIV PRESS