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Profiling cancer cells by cell-selex: Use of aptamers for discovery of actionable biomarkers and therapeutic applications thereof

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Version 2 2024-06-19, 08:05
Version 1 2022-01-12, 08:43
journal contribution
posted on 2024-06-19, 08:05 authored by Sarah ShigdarSarah Shigdar, L Agnello, M Fedele, S Camorani, L Cerchia
The identification of tumor cell-specific surface markers is a key step towards personalized cancer medicine, allowing early assessment and accurate diagnosis, and development of efficacious targeted therapies. Despite significant efforts, currently the spectrum of cell membrane targets associated with approved treatments is still limited, causing an inability to treat a large number of cancers. What mainly limits the number of ideal clinical biomarkers is the high complexity and heterogeneity of several human cancers and still-limited methods for molecular profiling of specific cancer types. Thanks to the simplicity, versatility and effectiveness of its application, cell-SELEX (Systematic Evolution of Ligands by Exponential Enrichment) technology is a valid complement to the present strategies for biomarkers’ discovery. We and other researchers worldwide are attempting to apply cell-SELEX to the generation of oligonucleotide aptamers as tools for both identifying new cancer biomarkers and targeting them by innovative therapeutic strategies. In this review, we discuss the potential of cell-SELEX for increasing the currently limited repertoire of actionable cancer cell-surface biomarkers and focus on the use of the selected aptamers as components of innovative conjugates and nano-formulations for cancer therapy.

History

Journal

Pharmaceutics

Volume

14

Article number

28

Pagination

1-20

Location

Basel, Switzerland

Open access

  • Yes

ISSN

1999-4923

eISSN

1999-4923

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Issue

1

Publisher

MDPI AG