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Progression of cardiovascular and endocrine dysfunction in a rabbit model of obesity
journal contribution
posted on 2013-01-01, 00:00 authored by G Eppel, James ArmitageJames Armitage, N Eikelis, G Head, R EvansIn rabbits, mean arterial pressure (MAP) increases in response to fat feeding, but does not increase further with progressive weight gain. We documented the progression of adiposity and the alterations in endocrine/cardiovascular function in response to fat feeding in rabbits, to determine whether stabilization of MAP after 3 weeks could be explained by stabilization of neurohormonal factors. Rabbits were fed a control diet or high-fat diet for 9 weeks (n¼23). Fat feeding progressively increased body mass and adiposity. Heart rate (HR) was elevated by week 3 (15±3%) but changed little thereafter. The effects of fat feeding on MAP were dependent on baseline MAP and peaked at 3 weeks. From baseline, MAP p80mmHg, MAP had increased by 8.1±1.3, 4.7±1.7 and 5.6±1.2mmHg, respectively, 3, 6 and 9 weeks after commencing the high-fat diet, but by only 2.6±1.5, 3.0±1.7 and 3.9±1.4mmHg, respectively, in control rabbits. Fat feeding did not increase MAP from a baseline 480mmHg. Plasma concentrations of leptin and insulin increased during the first 3–6 weeks of fat feeding and then stabilized (increasing by 111±17% and 731±302% by week 9, respectively), coinciding with the pattern of changes in MAP and HR. Plasma total cholesterol, triglycerides, renin activity, aldosterone and atrial natriuretic peptide were not significantly altered by fat feeding. Given that the changes in plasma leptin and insulin mirrored the changes in MAP and HR, leptin and insulin may be important factors in the development of hypertensionand tachycardia in the rabbit model of obesity.
History
Journal
Hypertension researchVolume
36Pagination
588 - 595Publisher
Nature Publishing GroupLocation
London, EnglandPublisher DOI
Link to full text
ISSN
0916-9636eISSN
1348-4214Language
engPublication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
atrial natriuretic peptidedual - energy X-ray absorptometryinsulinleptinrenin-angiotensin-aldosterone systemScience & TechnologyLife Sciences & BiomedicinePeripheral Vascular DiseaseCardiovascular System & Cardiologydual-energy X-ray absorptometrySYMPATHETIC-NERVE ACTIVITYBLOOD-PRESSUREHIGH-FATHEART-RATEINDUCED HYPERTENSIONDIURNAL RHYTHMSBODY-MASSACTIVATIONHYPERINSULINEMIA
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