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Progression of lipodystrophy (LD) with continued thymidine analogue usage: long-term follow-up from a randomized clinical trial (the PIILR study)
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posted on 2004-07-01, 00:00 authored by A Martin, D Smith, A Carr, J Hoy, J Chuah, S Mallal, M Law, M Clements, D A Cooper, D Wheatley, David AustinDavid Austin, The PIILR Study GroupPurpose: During the 24-week PIILR study of protease inhibitor (PI) withdrawal, improved lipids and reduction in intraabdominal visceral fat was seen, however, there was also a loss of subcutaneous limb fat in patients with HIV-lipodystrophy (LD). It was hypothesized that overall improvement in LD may require a longer period of time off Pls. Method: Follow-up of patients randomized to stop or continue PI-based therapy for 24 weeks, in a multicenter study, was continued for up to 120 weeks. Biochemistry and lipid parameters were assessed every 3 months. DEXA and CT scans were performed annually. Limb fat, visceral adipose tissue, and the lipodystrophy case definition score (LCDS) were used as indicators of LD severity. Results: Forty-five male patients with baseline and week 120 body composition data were assessed. There were no significant changes in the limb fat or visceral adipose tissue (VAT) components of LD, with the exception of the LCDS (change from baseline +5.79, p < .001). Control of viral replication was maintained and lipid and glycemic parameters were unchanged over the 120-week follow-up. Linear regression analysis showed on-study usage of stavudine was independently and significantly correlated with both decreased limb fat mass and a higher LCDS. Conclusion: Body composition or metabolic features of LD did not improve over 2 years of observation in patients remaining on predominantly PI-sparing therapy. LD was adversely influenced by continued stavudine use. © 2004 Thomas Land Publishers, Inc.
History
Journal
HIV clinical trialsVolume
5Issue
4Pagination
192 - 200Publisher
Taylor & FrancisLocation
Abingdon, EngPublisher DOI
ISSN
1528-4336Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2004, Thomas Land Publishers, IncUsage metrics
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