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Prostanoids and adrenaline release: a study of [3H]adrenaline efflux from the rabbit isolated, perfused, adrenal gland.

Version 2 2024-06-03, 13:26
Version 1 2017-05-16, 15:13
journal contribution
posted on 2024-06-03, 13:26 authored by AR Collett, GJ Dusting, DF Story, M Purchase
[3H]Adrenaline was incorporated in an isolated perfused preparation of the rabbit adrenal gland and the effects of indomethacin, PGE2 and PGI2 on its release were investigated. Efflux of [3H]adrenaline was elicited by electrical stimulation of the splanchnic nerve (60 s at 5 Hz). Indomethacin (3 and 30 microM) had no effect on stimulation-induced efflux. PGE2 (30, 90 and 300 nM) reduced the efflux; with 90 nM PGE2 the inhibition amounted to approximately 30%. PGI2, in concentrations from 90 to 600 nM, was without effect. These findings indicate that release of [3H]adrenaline from the rabbit adrenal gland is not subject to modulation by endogenous adrenal prostaglandins; however, PGE2 may play a role in some pathological situations.

History

Journal

Journal of Pharmacy and Pharmacology

Volume

37

Pagination

188-192

Location

England

ISSN

0022-3573

eISSN

2042-7158

Language

eng

Publication classification

CN.1 Other journal article

Issue

3

Publisher

Wiley