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Protein conformational misfolding and amyloid formation: characteristics of a new class of disorders that include Alzheimer's and Prion diseases

journal contribution
posted on 2002-10-01, 00:00 authored by A J Thompson, Colin BarrowColin Barrow
The accumulation of proteinaceous deposits has been recognised to occur in several neurodegenerative conditions including Prion diseases, Alzheimer's disease, Parkinson's disease, and Huntington's disease. Over the last two decades interest in these conditions has increased markedly, fueled partially by an increasing prevalence of these diseases in the Western world. Evidence indicates that anomalous protein misfolding and aggregation, with an accompanying "toxic gain of function" is central to the neuropathogenesis of these diseases. An increased understanding of the similarities and differences in the production, aggregation and accumulation of the respective proteins involved in these diseases, and the associated mechanisms of neurodegeneration, should aid in the development of new therapeutic agents to treat this group of related disorders.

History

Journal

Current medicinal chemistry

Volume

9

Issue

19

Pagination

1751 - 1762

Publisher

Bentham Science Publishers

Location

Beijing, China

ISSN

0929-8673

eISSN

1875-533X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2002, Bentham Science Publishers