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Protein conformational misfolding and amyloid formation: characteristics of a new class of disorders that include Alzheimer's and Prion diseases
The accumulation of proteinaceous deposits has been recognised to occur in several neurodegenerative conditions including Prion diseases, Alzheimer's disease, Parkinson's disease, and Huntington's disease. Over the last two decades interest in these conditions has increased markedly, fueled partially by an increasing prevalence of these diseases in the Western world. Evidence indicates that anomalous protein misfolding and aggregation, with an accompanying "toxic gain of function" is central to the neuropathogenesis of these diseases. An increased understanding of the similarities and differences in the production, aggregation and accumulation of the respective proteins involved in these diseases, and the associated mechanisms of neurodegeneration, should aid in the development of new therapeutic agents to treat this group of related disorders.
History
Journal
Current medicinal chemistryVolume
9Issue
19Pagination
1751 - 1762Publisher
Bentham Science PublishersLocation
Beijing, ChinaPublisher DOI
ISSN
0929-8673eISSN
1875-533XLanguage
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2002, Bentham Science PublishersUsage metrics
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