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Protocol for a systematic review of the financial burden experienced by people affected by head and neck cancer
journal contribution
posted on 2022-02-01, 00:00 authored by Nikki McCaffreyNikki McCaffrey, Lidia EngelIntroductionHead and neck cancer (HNC) is the seventh most common cancer worldwide. Treatment may be associated with the inability to work and substantial out-of-pocket expenses. However, to date, there is little research synthesising quantitative evidence on the financial burden experienced by people affected by HNCs, including family members and informal carers. The purpose of this systematic review is to estimate out-of-pocket costs, reduced or lost income and informal care costs associated with HNC, identify categories of financial burden and investigate which costs predominate when considering financial burden in this population.Methods and analysisA comprehensive search of peer-reviewed literature will be conducted for articles published from 01/01/2010 to 19/03/2021 (CINAHL, Cochrane library, EconLit, Embase, Medline Complete). Published, English-language articles describing primary and secondary research directly related to the topic and quantitative cost data will be included. One researcher will complete the searches and screen results for potentially eligible studies. Three other researchers will independently screen the titles and abstracts of a subset of 30% citations, that is, 10% each. Full text articles will be independently screened by three reviewers. Any disagreement will be resolved by consensus among the team. Study and patient characteristics, cost categories and financial burden will be independently extracted by one reviewer and checked by a second. Methodological quality will be evaluated independently by two reviewers. Descriptive analyses will be undertaken and a narrative summary of the included studies will be provided.Ethics and disseminationEthics approval is not required to conduct this research because this is a planned systematic review of published literature. Findings will be presented at leading cancer and health economic conferences, published in a peer-reviewed journal and disseminated via website postings and social media channels.Systematic review registration numberCRD42021252929.
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Journal
BMJ OpenVolume
12Issue
2Article number
e055213Pagination
1 - 4Publisher
BMJLocation
London, EnglandPublisher DOI
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2044-6055eISSN
2044-6055Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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