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Psammomys obesus: a natural diet-controlled model for diabetes and cardiovascular diseases
journal contribution
posted on 2018-09-01, 00:00 authored by Rajneesh Chaudhary, Ken WalderKen Walder, Christoph E Hagemeyer, Jagat KanwarPURPOSE OF REVIEW: This review specifically summarises and reports terrestrial mammals of the gerbil subfamily, known as Israeli sand rats or Psammomys obesus (P. obesus) as a diet-controlled, unique, polygenic rodent model for research in the areas of obesity, type 2 diabetes, and cardiovascular diseases. The animal model closely mimics phenotypic and pathophysiological resemblance with human populations. RECENT FINDINGS: The physiological status and biochemical composition in P. obesus can be manipulated effectively by controlling its nutritional intake, making it a natural model for cardiovascular and diabetic research. Humans exhibit remarkable disparity in physiology and pathology, which are inter-dependent factors. However, variations in these factors in most animal models currently being used for cardiovascular/diabetes research are insignificant. Consequently, it is a necessity to identify and develop animal models exhibiting physiological variations mimicking human pathological conditions. We have compiled research developments conducted with this rodent model manifesting pathophysiology, closely mimicking that in human beings, thereby enabling better translation of novel therapeutic and diagnostic discoveries.
History
Journal
Current atherosclerosis reportsVolume
20Issue
9Article number
46Pagination
1 - 10Publisher
SpringerLocation
New York, N.Y.Publisher DOI
eISSN
1534-6242Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, Springer Science+Business Media, LLC, part of Springer NatureUsage metrics
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No categories selectedKeywords
AtherosclerosisCardiovascular diseasesDiabetesPsammomys obesusSand ratsScience & TechnologyLife Sciences & BiomedicinePeripheral Vascular DiseaseCardiovascular System & CardiologyACUTE MYOCARDIAL-INFARCTIONSMOOTH-MUSCLE-CELLSSAND RATINSULIN-RESISTANCEPERIOSTIN EXPRESSIONADIPOSE-TISSUEINFLAMMATIONGLICLAZIDEPROTEINS
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