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Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: network meta-analysis

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journal contribution
posted on 01.05.2017, 00:00 authored by Mary Lou Chatterton, E Stockings, Michael BerkMichael Berk, J J Barendregt, Rob CarterRob Carter, Cathy Mihalopoulos
BackgroundFew trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional meta-analyses provided limited comparisons between therapies.AimsTo combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA).MethodSystematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF).ResultsCarer-focused interventions significantly reduced the risk of depressive or manic relapse. Psychoeducation alone and in combination with cognitive-behavioural therapy (CBT) significantly reduced medication non-adherence. Psychoeducation plus CBT significantly reduced manic symptoms and increased GAF. No intervention was associated with a significant reduction in depression symptom scale scores.ConclusionsOnly interventions for family members affected relapse rates. Psychoeducation plus CBT reduced medication non-adherence, improved mania symptoms and GAF. Novel methods for addressing depressive symptoms are required.

History

Journal

British journal of psychiatry

Volume

210

Issue

5

Pagination

333 - 341

Publisher

Royal College of Psychiatrists

Location

London, Eng.

eISSN

1472-1465

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2017, Royal College of Psychiatrists