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Quantitation of suspected allergens in fragrances (part I): evaluation of comprehensive two-dimensional gas chromatography for quality control

journal contribution
posted on 2004-03-01, 00:00 authored by Robert ShellieRobert Shellie, P Marriott, A Chaintreau
An evaluation of comprehensive two-dimensional (2D) gas chromatography (GC×GC) was performed to assess its suitability for the analysis of volatile fragrance components, recognized by the European Commission's Scientific Committee on Cosmetics and other Non-food Products (SCCNFP) as possible skin sensitizers. The 24 volatile components listed by the SCCNFP were baseline-resolved or better within one 30 min analysis. High-quality calibration data for standard mixtures were obtained, with R2 > 0.998 over the concentration range 2-1000 mg/l. However, the analysis of small spiked amounts of target compounds in truly complex fragrances was problematic, due to uncertainty in component assignment. The benefits and limitations of GC×GC are reported, and a discussion of the proposed directions for the solution of this analysis is provided.

History

Journal

Flavour and fragrance journal

Volume

19

Season

Mar/Apr

Pagination

91-98

Location

Chichester, Eng.

ISSN

0882-5734

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2004, John Wiley & Sons, Ltd

Issue

2

Publisher

John Wiley & Sons

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