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Quercetin and Osteoarthritis: A Mechanistic Review on the Present Documents

Version 2 2024-08-15, 23:38
Version 1 2023-04-03, 05:35
journal contribution
posted on 2024-08-15, 23:38 authored by Faezeh Samadi, Mohammad Saeed Kahrizi, Fateme Heydari, Reza Arefnezhad, Hossein Roghani-Shahraki, Abnoos Mokhtari Ardekani, Fatemeh Rezaei-Tazangi
Background: Osteoarthritis (OA), as one of the chronic debilitating conditions, affects 15% of people globally and is linked with serious problems, such as cardiovascular diseases, metabolic syndrome, and autoimmune inflammatory disorders. The current therapeutic options for this disease include nonsteroidal anti-inflammatory drugs, surgery, gene therapy, intrasynovial gel injection, and warm needle penetration. However, these approaches may be accompanied by considerable side effects, high costs, and some limitations for patients. Thus, using an alternative way is needed. Summary: Presently, natural compounds based-therapies, like flavonoids, have acquired much attention in the current era. One of the compounds belonging to the flavonoid family is quercetin, and its therapeutic effects on disorders related to joints and cartilage have been addressed in vivo and in vitro studies. Key Messages: In this review, we summarized evidence indicating its curative capacity against OA with a mechanistic insight.

History

Journal

Pharmacology

Volume

107

Pagination

464-471

Location

Basel, Switzerland

ISSN

0031-7012

eISSN

1423-0313

Language

en

Publication classification

C1 Refereed article in a scholarly journal

Issue

9-10

Publisher

Karger