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Randomized controlled study of the urinary excretion of biophenols following acute and chronic intake of olive leaf supplements
journal contribution
posted on 2012-02-01, 00:00 authored by M Kendall, M Batterham, Damien CallahanDamien Callahan, D Jardine, P D Prenzler, K Robards, D RyanOlive leaf supplement was characterised by HPLC and administered to healthy young adults over 28 d (three tablets or equivalent liquid dose per day), or in a single bolus dose of three tablets (or liquid equivalent). Oleuropein was the major biophenol in the extracts. There are no data on the excretion of urinary end-products of the metabolism of the olive leaf biophenols. Following both chronic and acute ingestion neither oleuropein, nor its hydrolysis product, hydroxytyrosol, were detected in urine samples. However, glucuronic acid conjugates, derived from oleuropein aglycone were detected in all urine samples up to 6 h following acute ingestion. The data suggest that oleuropein is bioavailable, which is a necessary pre-condition for bioactivity.
History
Journal
Food chemistryVolume
130Issue
3Pagination
651 - 659Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0308-8146Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2012, ElsevierUsage metrics
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