Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design

Donald, Alastair; McHardy, Tatiana; Rowlands, Martin G; Hunter, Lisa-Jane K; Davies, Thomas G; Berdini, Valerio; Boyle, Robert G; Aherne, G Wynne; Garrett, Michelle D; Collins, Ian

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design

https://hdl.handle.net/10779/DRO/DU:26786827

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posted on 2024-08-20, 05:34 authored by Alastair Donald, Tatiana McHardy, Martin G Rowlands, Lisa-Jane K Hunter, Thomas G Davies, Valerio Berdini, Robert G Boyle, G Wynne Aherne, Michelle D Garrett, Ian CollinsIan Collins

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design

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DOI - Is version of https://doi.org/10.1021/jm0700924

Location

United States

Language

English

Author URL

https://www.ncbi.nlm.nih.gov/pubmed/17451235

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C1 Refereed article in a scholarly journal

Journal

JOURNAL OF MEDICINAL CHEMISTRY

Volume

50

Pagination

2289-2292

ISSN

0022-2623

eISSN

1520-4804

Issue

10

Publisher

AMER CHEMICAL SOC

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http://dx.doi.org/10.1021/jm0700924

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Keywords

Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy SMALL-MOLECULE INHIBITORS CANCER DRUG DISCOVERY SELECTIVE INHIBITORS PATHWAY COMPLEX PKB PROGRESS MUTANTS BINDING TARGET

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design

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