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Rational design of additively manufactured Ti6Al4V implants to control Staphylococcus aureus biofilm formation

journal contribution
posted on 01.03.2019, 00:00 authored by A Sarker, N Tran, Aaqil RifaiAaqil Rifai, M Brandt, P A Tran, M Leary, K Fox, Richard WilliamsRichard Williams
Bacterial attachment and subsequent biofilm formation on medical implants presents a serious infection risk. The precision, personalisation and superior functionality of additive manufacturing techniques, such as selective laser melting (SLM), enables the fabrication of metallic implants with patient specific customisation. An unexpected outcome of this process, however, is a hitherto unachievable fine control over the bio-interface in a single manufacturing step. Here, for the first time, we report on how the SLM build inclination angle can be utilised to modify the surface topography of metallic implants for directed Staphylococcus aureus biofilm restriction. From an initial build inclination angle of 90°, lowering the angle gave metallic surfaces with lower roughness, lower hydrophobicity, higher surface energy, and fewer partially melted metal particles without altering the bulk surface chemistry. This directly correlated with significantly lower biofilm coverage and an associated reduction in biomass without compromising mammalian cell viability and attachment. This work provides facile single step method at the manufacturing stage for the development of additively manufactured metallic implants with superior, inherent protection against implant associated infection.

History

Journal

Materialia

Volume

5

Article number

100250

Pagination

1 - 13

Publisher

Elsevier

Location

Amsterdam, The Netherlands

eISSN

2589-1529

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, Acta Materialia Inc.