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Reboxetine add on therapy to haloperidol in the treatment of schizophrenia: a preliminary double-blind randomized placebo-controlled study.
journal contributionposted on 2001-09-01, 00:00 authored by G Schutz, Michael BerkMichael Berk
The negative symptoms of schizophrenia remain a major clinical challenge. Reboxetine is an antidepressant whose major mechanism of action is as a noradrenergic reuptake inhibitor. This study was a 6-week randomized placebo-controlled trial of reboxetine or placebo add on to haloperidol 5 mg in the treatment of 30 patients with DSM-IV schizophrenia. The trial failed to demonstrate any significant difference between the placebo and reboxetine groups on any of the outcome measures. This trial does not suggest that increased noradreneregic drive mediated by reuptake inhibition in patients taking dopamine antagonists is of therapeutic value in schizophrenia.
JournalInternational Clinical Psychopharmacology
Pagination275 - 278
PublisherLippincott, Williams & Wilkins
Publication classificationC1.1 Refereed article in a scholarly journal
Copyright notice2001, Lippincott, Williams & Wilkins
AdultAntidepressive AgentsChronic DiseaseDepressionDouble-Blind MethodDrug Therapy, CombinationFemaleHaloperidolHumansMaleMorpholinesPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyTreatment OutcomeScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyPsychiatryreboxetineCLONIDINE TREATMENTNOREPINEPHRINEIDAZOXANDRUGS