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Reboxetine add on therapy to haloperidol in the treatment of schizophrenia: a preliminary double-blind randomized placebo-controlled study.
The negative symptoms of schizophrenia remain a major clinical challenge. Reboxetine is an antidepressant whose major mechanism of action is as a noradrenergic reuptake inhibitor. This study was a 6-week randomized placebo-controlled trial of reboxetine or placebo add on to haloperidol 5 mg in the treatment of 30 patients with DSM-IV schizophrenia. The trial failed to demonstrate any significant difference between the placebo and reboxetine groups on any of the outcome measures. This trial does not suggest that increased noradreneregic drive mediated by reuptake inhibition in patients taking dopamine antagonists is of therapeutic value in schizophrenia.
History
Journal
International Clinical PsychopharmacologyVolume
16Issue
5Pagination
275 - 278Publisher
Lippincott, Williams & WilkinsLocation
EnglandISSN
0268-1315Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2001, Lippincott, Williams & WilkinsUsage metrics
Categories
Keywords
AdultAntidepressive AgentsChronic DiseaseDepressionDouble-Blind MethodDrug Therapy, CombinationFemaleHaloperidolHumansMaleMorpholinesPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyTreatment OutcomeScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyPsychiatryreboxetineCLONIDINE TREATMENTNOREPINEPHRINEIDAZOXANDRUGS