yang-recentadvancementof-2020.pdf (3.02 MB)
Download file

Recent advancement of biosensor technology for the detection of microcystin-LR

Download (3.02 MB)
journal contribution
posted on 2020-01-01, 00:00 authored by Pengfei Pang, Y Lai, Y Zhang, H Wang, Xavier ConlanXavier Conlan, Colin BarrowColin Barrow, Wenrong YangWenrong Yang
Microcystins are a class of toxins that are mainly produced by cyanobacteria and among them, microcystin-leucine arginine (microcystin-LR) is one of the most toxic and harmful of the fresh water toxins causing many accidents and threats to human health. The detection of microcystin-LR in drinking water and environmental water samples is therefore crucial. To date, methods such as high performance liquid chromatography, protein phosphatase inhibition assay, enzyme-linked immunosorbent assay, and Raman spectroscopy have been employed to monitor microcystin-LR levels. Although these techniques are precise and sensitive, they require expensive instrumentation, well-trained personnel and involve time-consuming processes meaning that their application is generally limited to well-resourced and centralized laboratory facilities. Among the emerging microcystin-LR detection methods, biosensors have received great attention because of their remarkable sensitivity, selectivity, and simplicity. In this review, we will discuss the current state-of-the-art microcystin-LR biosensing platforms, and evaluate the advantages and limitations of typical transduction technologies to identify the most efficient detection system for the potentially harmful cyanobacteria.

History

Journal

Bulletin of the Chemical Society of Japan

Volume

93

Issue

5

Pagination

637 - 646

Publisher

Chemical Society of Japan

Location

Tokyo, Japan

ISSN

0009-2673

eISSN

1348-0634

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal