suphioglu-recentadvances-2021.pdf (886.43 kB)
Recent advances in the inhibition of the il-4 cytokine pathway for the treatment of allergen-induced asthma
journal contribution
posted on 2021-01-01, 00:00 authored by Oliver MasseyOliver Massey, Cenk SuphiogluCenk SuphiogluThe IL-4 and IL-13 cytokine pathways play integral roles in stimulating IgE inflammation, with the IL-4 cytokine being a major cytokine in the etiology of thunderstorm asthma, atopic dermatitis, and allergic rhinitis. The increasing prevalence of thunderstorm asthma in the younger population and the lessening efficacy of corticosteroids and other anti-inflammatories has created a need for more effective pharmaceuticals. This review summarizes the IL-4 and IL-13 pathways while highlighting and discussing the current pathway inhibitors aimed at treating thunderstorm asthma and atopic dermatitis, as well as the potential efficacy of peptide therapeutics in this field.
History
Journal
International Journal of Molecular SciencesVolume
22Issue
24Article number
13655Pagination
1 - 10Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
Link to full text
ISSN
1661-6596eISSN
1422-0067Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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Keywords
ACTIVATIONBiochemistry & Molecular BiologyChemistryChemistry, MultidisciplinaryDOUBLE-BLINDDUPILUMABEFFICACYEXPRESSIONimmunoglobulin E (IgE)immunotherapyinterleukin 13 (IL-13)interleukin 4 (IL-4)LEBRIKIZUMABLife Sciences & BiomedicineMONOCLONAL-ANTIBODYpeptide therapeuticsPhysical SciencesPROLIFERATIONSAFETYScience & TechnologySTAT6Genetics
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