russell-recentadvances-2018.pdf (849.58 kB)
Recent advances in understanding the role of FOXO3 [version 1; referees: 4 approved]
journal contribution
posted on 2018-08-31, 00:00 authored by Renae J Stefanetti, Sarah Voisin, Aaron RussellAaron Russell, Severine LamonSeverine LamonThe forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of transcription factors. FOXO proteins were originally identified as regulators of insulin-related genes; however, they are now established regulators of genes involved in vital biological processes, including substrate metabolism, protein turnover, cell survival, and cell death. FOXO3 is one of the rare genes that have been consistently linked to longevity in in vivo models. This review provides an update of the most recent research pertaining to the role of FOXO3 in (i) the regulation of protein turnover in skeletal muscle, the largest protein pool of the body, and (ii) the genetic basis of longevity. Finally, it examines (iii) the role of microRNAs in the regulation of FOXO3 and its impact on the regulation of the cell cycle.
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Journal
F1000ResearchVolume
7Article number
1372Pagination
1 - 8Publisher
F1000Research LtdLocation
London, Eng.Publisher DOI
Link to full text
ISSN
2046-1402eISSN
1759-796XLanguage
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, Stefanetti RJ et al.Usage metrics
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