russell-recentadvances-2018.pdf (849.58 kB)
Download file

Recent advances in understanding the role of FOXO3 [version 1; referees: 4 approved]

Download (849.58 kB)
journal contribution
posted on 31.08.2018, 00:00 authored by Renae J Stefanetti, Sarah Voisin, Aaron RussellAaron Russell, Severine LamonSeverine Lamon
The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of transcription factors. FOXO proteins were originally identified as regulators of insulin-related genes; however, they are now established regulators of genes involved in vital biological processes, including substrate metabolism, protein turnover, cell survival, and cell death. FOXO3 is one of the rare genes that have been consistently linked to longevity in in vivo models. This review provides an update of the most recent research pertaining to the role of FOXO3 in (i) the regulation of protein turnover in skeletal muscle, the largest protein pool of the body, and (ii) the genetic basis of longevity. Finally, it examines (iii) the role of microRNAs in the regulation of FOXO3 and its impact on the regulation of the cell cycle.

History

Journal

F1000Research

Volume

7

Article number

1372

Pagination

1 - 8

Publisher

F1000Research Ltd

Location

London, Eng.

ISSN

2046-1402

eISSN

1759-796X

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, Stefanetti RJ et al.