rajkhowa-recentinnovations-2010.pdf (916.99 kB)
Download fileRecent innovations in silk biomaterials
journal contribution
posted on 2010-01-01, 00:00 authored by Rangam RajkhowaRangam Rajkhowa, Takuya Tsuzuki, Xungai WangXungai WangSilk contains a fibre forming protein, fibroin, which is biocompatible, particularly after removing the potentially immunogenic non-fibroin proteins. Silk can be engineered into a wide range of materials with diverse morphologies. Moreover, it is possible to regenerate fibroin with a desired amount of crystallinity, so that the biodegradation of silk materials can be controlled. These advantages have sparked new interest in the use of silk fibroin for biomedical applications, including tissue engineering scaffolds and carriers for sustained release of biologically active molecules. This article summarizes the current research related to the formation of silk materials with different morphologies, their biocompatibility, and examples of their biomedical applications. Recent work on the preparation of silk particles by mechanical milling and their applications in silk composite scaffolds is also discussed.
History
Journal
Journal of fiber bioengineering and informaticsVolume
2Issue
4Pagination
202 - 213Publisher
Binary Information PressLocation
Bethel, Conn.ISSN
1940-8676Language
engNotes
This paper was also presented at TBIS 2010 : Textile Bioengineering and Informatics Symposium Proceedings : Greener Textiles, Healthier Life on 28-30 May 2010.Publication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2010, Binary Information PressUsage metrics
Categories
Keywords
silk fibroinpowdercompositemorphologyapplicationScience & TechnologyTechnologyEngineering, BiomedicalMaterials Science, BiomaterialsEngineeringMaterials ScienceBOMBYX-MORI-SILKMESENCHYMAL STEM-CELLSCEREBRAL ARTERIOVENOUS-MALFORMATIONSIN-VITROFIBROBLAST CELLSFINE-STRUCTURESTRUCTURAL CHARACTERISTICSFIBROIN MEMBRANE3-D SCAFFOLDSGROWTH