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Recognition of chiral zwitterionic interactions at nanoscale interfaces by chiroplasmonic nanosensors
journal contribution
posted on 2017-08-28, 00:00 authored by Wenjing Zhao, Rong-Yao Wang, Hong Wei, Jingliang LiJingliang Li, Yinglu Ji, Xinxin Jiang, Xiaochun Wu, Xiangdong ZhangThe ability to detect chiral molecules renders plasmonic nanosensors as promising tools for the study of chirality phenomena in living systems. Using gold nanorod based plasmonic nanosensors, we investigated here typically chiral zwitterionic electrostatic (Zw-Es) and hydrogen-bonding (Hb) interactions occurring via amine and carboxylic groups at nanoscale interfaces in aqueous solutions. Our results reveal that the plasmonic circular dichroism responses of the nanosensors can have both conformational sensitivity and chiral selectivity to the interfacial molecular interactions. Such a dual function of the plasmonic nanosensors enables a new chiroptical way to differentiate between chiral Zw-Es and Hb interactions, to monitor the transformation between these two interaction forces, and particularly to recognize homochiral Zw-Es interactions in solution. Together with the surface enhanced Raman scattering (SERS) technique, this plasmonic CD based biosensing could have important values for the insightful understanding of chirality-dependent molecular recognition in biological and pharmaceutical systems.
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Journal
Physical chemistry chemical physicsVolume
19Issue
32Pagination
21401 - 21406Publisher
Royal Society of ChemistryLocation
Cambridge, Eng.Publisher DOI
eISSN
1463-9084Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2017, the Owner SocietiesUsage metrics
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chiral zwitterionic interactionsnanoscale interfaceschiroplasmonic nanosensorschiral moleculesplasmonic nanosensorschirality phenomenaliving systemsScience & TechnologyPhysical SciencesChemistry, PhysicalPhysics, Atomic, Molecular & ChemicalChemistryPhysicsENHANCED RAMAN-SCATTERINGCIRCULAR-DICHROISMGOLD NANORODSOPTICAL-ACTIVITYL-CYSTEINEMOLECULESPLASMONNANOPARTICLESENANTIOMERSMONOLAYERS
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